What is an endocrine disruptor (ED)?
They are substances or mixtures of substances that alter the function of the endocrine system causing adverse effects to the health of organisms, their offspring or their populations.
Is it possible to simultaneously detect the three types of endocrine disruptors in the same sample?
From a single sample we can evaluate the presence of endocrine disruptors with the capacity to activate or block the estrogen, androgen and thyroid hormone receptors.
Does the technique allow the detection of different estrogens, androgens and thyroid hormones?
Using in vitro bioassays for transactivation of the luciferase gene, we do not identify the substances responsible for activating or blocking hormone receptors. We globally evaluate the hormonal or anti-hormonal activity of the sample, taking into account synergistic, additive or antagonistic reactions that can occur in samples as complex as environmental ones.
What quantity of sample is necessary to allow the detection of EDs?
The amount of sample that is needed is small, our extraction methodology has been fine-tuned to work with quantities around 10-30 g of dry weight and with less than 1L in the case of liquid samples.