Titulo de la pagina
Efectos de Contaminantes Ambientales

Nuestro objetivo principal es estudiar los mecanismos subyacentes a la toxicidad de contaminantes emergentes (e.g. nanomateriales, disruptores endocrinos, biocidas o micotoxinas) y su bioacumulación en organismos acuáticos, particularmente en peces, mediante aproximaciones in vitro e in vivo. Además, desarrollamos metodologías de evaluación del riesgo medioambiental y estudiamos posibles resistencias a estos contaminantes.

Grupo de investigación dependiente del

Departamento de Medio Ambiente y Agronomía

La contaminación de los cursos de agua supone una grave amenaza para los ecosistemas y para la salud humana. Una de las principales fuentes de contaminación es el sector agroalimentario, en particular las prácticas agrícolas intensivas en las que se requiere el uso de sustancias químicas o nanomateriales que pueden producir efectos nocivos en los organismos acuáticos y en el ser humano. Nuestro grupo de investigación centra su trabajo en el estudio de la toxicidad de contaminantes, su bioacumulación y las alteraciones endocrinas que pueden causar sobre los organismos acuáticos. Estudiamos fundamentalmente los efectos de:

Nanomateriales
Residuos Agroalimentarios
Micotoxinas
Biocidas

El objetivo final es generar información y desarrollar las herramientas necesarias para evaluar los peligros de estas sustancias para el medioambiente y el ser humano. El conocimiento generado permite realizar diagnósticos del estado ambiental de áreas concretas, lo utilizan las agencias reguladoras para desarrollar herramientas de evaluación del riesgo y la industria para diseñar sistemas de producción y productos seguros.

Investigación

Nanomateriales

Los nanomateriales (NMs) son partículas con al menos una de sus dimensiones entre 1 nm y 100 nm. Poseen una elevada superficie con respecto a su volumen lo que les confiere propiedades muy particulares por lo que se están introduciendo de manera exponencial en el mercado para usos en diferentes sectores incluyendo el agroalimentario. Sin embargo, el conocimiento sobre sus efectos adversos es muy limitado.

Nuestros estudios han permitido determinar que los NMs: a) son tóxicos para las células de peces y para los organismos acuáticos en mayor o menor medida, dependiendo fundamentalmente de su naturaleza química y ejerciendo mecanismos de toxicidad específicos; b) son capaces de internalizarse en la célula acumulándose en diferentes orgánulos según su naturaleza; c) son absorbidos por los peces, distribuyéndose a diferentes órganos y bioacumulándose según el tipo de NM; d) pueden interaccionar entre sí produciendo efectos tóxicos más pronunciados (sinérgicos).

Residuos agroalimentarios

Hemos estudiado en detalle la actividad de disrupción endocrina (actividad estrogénica, androgénica y tiroidea) de residuos de gallinaza y purines. Hemos observado una carga hormonal importante, relacionada fundamentalmente con la presencia de hormonas naturales, de modo que la aplicación prolongada de estos residuos como enmienda agrícola puede causar efectos nocivos en los suelos y afectar a las aguas subterráneas.

Micotoxinas

Las micotoxinas son metabolitos secundarios de hongos filamentosos que contaminan productos vegetales y que presentan elevada toxicidad. La introducción reciente de las harinas vegetales en piensos para peces puede suponer un riesgo para los peces y para el consumidor. Hemos caracterizado in vitro la toxicidad y el efecto hormonal de varias micotoxinas y estamos estudiando estrategias para bloquear el efecto tóxico de estas sustancias naturales.

Biocidas

El uso de biocidas para el control de organismos nocivos está muy extendido por lo que su presencia en el medio acuático es conocida. Presentan una elevada toxicidad para los organismos acuáticos pero se desconoce el efecto tóxico de la mayoría de sus metabolitos. Hemos generado una herramienta in silico predictiva de la toxicidad de estas sustancias en algas, dafnias, peces y microorganismos. También hemos observado que los estudios de toxicidad en células de pez permiten predecir satisfactoriamente la toxicidad en peces.

También estamos estudiando la aparición de resistencias a rodenticidas anticoagulantes en poblaciones de roedores de toda España.

Miembros

Coordinador de Grupo

Mª Luisa Fernández Cruz

Personal investigador

José Mª Navas Antón
María Luisa Fernández Cruz
David Hernández Moreno
Azucena Bermejo Nogales

Personal técnico

Ana Valdehita Torija
Eva Pose Juan
Javier Hernández Gonzalo

Personal

Mona Connolly
Mariia Goncharova
Cristina Magaña de Larriva
Noelia Marin Prat
Pilar Muñoz del Rio
David Ocampo Martin
Marta Portoles Mendez
Alicia Santos Expósito

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- Pulido-Reyes G., Moreno-Martín G., Gómez-Gómez B., Navas J.M., Madrid Y., Fernández-Cruz, M.L. (2024)
  Fish acute toxicity of nine nanomaterials: Need of pre-tests to ensure comparability and reuse of data
  Environmental Research | 245
  DOI: 10.1016/j.envres.2023.118072
- Lin H., Buerki-Thurnherr T., Kaur J., Wick P., Pelin M., Tubaro A., Carniel F., C., Tretiach M., Flahaut E., Iglesias D., Vázquez E., Cellot G., Ballerini L., Castagnola V., Benfenati F., Armirotti A., Sallustrau A., Taran F., Keck M., Bussy C., Vranic S., Kostarelos K., Connolly M., Navas J.M., Mouchet F., Gauthier L., Baker J., Suarez-Merino B., Kanerva T., Prato M., Fadeel B., Bianco A. (2024)
  Environmental and Health Impacts of Graphene and Other Two-Dimensional Materials: A Graphene Flagship Perspective
  ACS Nano | 18
  DOI: 10.1021/acsnano.3c09699
- Hernández-Moreno D., Fernández-Díaz M., Rucandio I., Navas J.M., Fernández-Cruz M.L. (2024)
  Toxic Effects of Different Coating-Related Functionalized Nanoparticles on Aquatic Organisms
  | 12
  DOI: 10.3390/toxics12020142
- Molés G., Connolly M., Valdehita A., Pulido-Reyes G., Fernandez-Cruz, M.L., Flahaut E., Navas, J.M. (2024)
  Testing the Aquatic Toxicity of 2D Few-Layer Graphene Inks Using Rainbow Trout (Oncorhynchus mykiss): In Vivo and In Vitro Approaches to Support an SSbD Assessment
  Toxics | 12
  DOI: 10.3390/toxics12020097
- Corredor-Santamaría, W., Calderón-Delgado, I.C., Arbeli, Z., Navas, J.M., Velasco-Santamaría, Y.M. (2023)
  Acute effects on hepatic biomarkers in the freshwater native fish Aequidens metae exposed to polycyclic aromatic hydrocarbons
  Global Journal of Environmental Science and Management | 9 : 1-14
  DOI: 10.22034/gjesm.2023.01.01
- Vizuete J., Pérez-López M, López-Beceiro A., Fidalgo L.E., Soler F., Míguez-Santiyán M.P., Hernández-Moreno D. (2023)
  Biochemical Effects of Heavy Metals and Organochlorine Compounds Accumulated in Different Tissues of Yellow-Legged Gulls (Larus Michahellis)
  Bulletin of Environmental Contamination and Toxicology | 110
  DOI: 10.1007/s00128-023-03729-1
- Judit Kalman, Mona Connolly, Fazel Abdolahpur-Monikh, Rocío Fernández-Saavedra, Ana I Cardona-García, Estefanía Conde-Vilda, Salome Martínez-Morcillo, Willie J G M Peijnenburg, Isabel Rucandio, María Luisa Fernández-Cruz (2023)
  Bioaccumulation of CuO nanomaterials in rainbow trout: Influence of exposure route and particle shape
  Chemosphere | 310
  DOI: 10.1016/j.chemosphere.2022.136894
- Connolly M, Martínez-Morcillo S, Kalman J, Navas JM, Bleeker E, Fernández-Cruz ML (2023)
  Considerations for bioaccumulation studies in fish with nanomaterials
  Chemosphere | 312
  DOI: 10.1016/j.chemosphere.2022.137299
- M Connolly, G Moles, F Candotto Carniel, M Tretiach, G Caorsi, E Flahaut, B Soula, E Pinelli, L Gauthier, F Mouchet, J M Navas (2022)
  Applicability of OECD TG 201, 202, 203 for the aquatic toxicity testing and assessment of 2D Graphene material nanoforms to meet regulatory needs
  NanoImpact | 29
  DOI: 10.1016/j.impact.2022.100447
- Hernández-Moreno, D., Navas, J.M., Fernández-Cruz, M.L. (2022)
  Short and long-term effects of nanobiomaterials in fish cell lines. Applicability of RTgill-W1
  Chemosphere | 309
  DOI: 10.1016/j.chemosphere.2022.136636
- Beatriz Albero, Mª Luisa Fernández Cruz, Rosa Ana Pérez, (2022)
  Simultaneous Determination of 15 Mycotoxins in Aquaculture Feed by Liquid Chromatography–Tandem Mass Spectrometry
  Toxins | 14
  DOI: 10.3390/toxins14050316
- Vizuete, J., Hernández-Moreno, D., López-Beceiro, A., Fidalgo, L.E., Soler, F., Pérez-López, M., Míguez-Santiyán, M.P. (2022)
  Heavy metals and metalloid levels in the tissues of yellow-legged gulls (Larus michahellis) from Spain: sex, age and geographical location differences.
  Environmental Science and Pollution Research | 29 : 54292-54308
  DOI: 10.1007/s11356-022-19627-8
- Bermejo-Nogales A; Rodríguez Martín J.A; Coll J; Navas J.M; (2022)
  VKORC1 single nucleotide polymorphisms in rodents in Spain
  Chemosphere
  DOI: 10.1016/j.chemosphere.2022.136021
- Badetti E; Brunelli A; Faraggiana E; Kalman J; Bettiol C; Izzo F.C; Navas J.M; Marcomini A; (2022)
  Cytotoxicity inhibition of catechol's type molecules by grafting on TiO2 and Fe2O3 nanoparticles surface
  Aquatic Toxicology
  DOI: 10.1016/j.aquatox.2022.106291
- Kalman J; Torrent F; Navas J.M; (2022)
  Cytotoxicity of three graphene-related materials in rainbow trout primary hepatocytes is not associated to cellular internalization
  Ecotoxicology and Environmental Safety
  DOI: 10.1016/j.ecoenv.2022.113227
- Hernández-Moreno, D., Blázquez, M., Navas, J.M., Fernández-Cruz, M.L. (2022)
  Fish cell lines as screening tools to predict acute toxicity to fish of biocidal active substances and their relevant environmental metabolite
  Aquatic Toxicology | 242
  DOI: 10.1016/j.aquatox.2021.106020
- Connolly, M., Hernández-Moreno, D., Conde, E., Garnica, A., Navas, J.M., Torrent, F., Rucandio, I., Fernández-Cruz, M.L. (2022)
  Influence of citrate and PEG coatings on the bioaccumulation of TiO2 and CeO2 nanoparticles following dietary exposure in rainbow trout.
  Environmental Sciences Europe | 34
  DOI: 10.1186/s12302-021-00581-0
- Ibarra, D., Martín-Sampedro, R., Wicklein, B., Borrero-López, A.M., Valencia, C., Valdehíta, A., Navas, J.M., Eugenio, M.E. (2022)
  Populus alba L., an autochthonous species of spain: A source for cellulose nanofibers by chemical pretreatment
  Polymers | 14
  DOI: 10.3390/polym14010068
- Hund-Rinke, K., Diaz, C., Jurack, A., Klein, J., Knopf, B., Schlich, K., Fernández-Cruz, M.L., Hernández-Moreno, D., Manier, N., Pandard, P., Gomes, S.I.L., Guimarães, B., Scott-Fordsmande, J.J., Amorim, M.J.B. (2021)
  Nanopharmaceuticals (Au-NPs) and regulation after use: Experiences with a complex higher tier test design simulating environmental fate and effect
  Ecotoxicology and Environmental Safety | 227
  DOI: 10.1016/j.ecoenv.2021.112949
- Hernández-Moreno, D., Ramos Martínez, A., Romay Cousido, C.M., Fidalgo, L.E., Menozzi, A., Bertini, S. (2021)
  Heavy metals content in Great Shearwater (Ardenna gravis): accumulation, distribution and biomarkers of effect in different tissues.
  Archives of Environmental Contamination and Toxicology | 80 : 615-623
  DOI: 10.1007/s00244-021-00828-0
- Bernal-Algaba E; Pulgarín-Alfaro M; Fernández-Cruz M.L; (2021)
  Cytotoxicity of mycotoxins frequently present in aquafeeds to the fish cell line rtgill-w1
  Toxins
  DOI: 10.3390/toxins13080581
- Corredor-Santamaría W; Mora-Solarte D.A; Arbeli Z; Navas J.M; Velasco-Santamaría Y.M; (2021)
  Liver biomarkers response of the neotropical fish Aequidens metae to environmental stressors associated with the oil industry
  Heliyon
  DOI: 10.1016/j.heliyon.2021.e07458
- Jeliazkova N; Apostolova M.D; Andreoli C; Barone F; Barrick A; Battistelli C; Bossa C; Botea-Petcu A; Châtel A; De Angelis I; Dusinska M; El Yamani N; Gheorghe D; Giusti A; Gómez-Fernández P; Grafström R; Gromelski M; Jacobsen N.R; Jeliazkov V; Jensen K.A; Kochev N; Kohonen P; Manier N; Mariussen E; Mech A; Navas J.M; Paskaleva V; Precupas A; Puzyn T; Rasmussen K; Ritchie P; Llopis I.R; Rundén-Pran E; Sandu R; Shandilya N; Tanasescu S; Haase A; Nymark P; (2021)
  Towards FAIR nanosafety data
  Nature Nanotechnology
  DOI: 10.1038/s41565-021-00911-6
- Blázquez M; Andreu-Sánchez O; Ballesteros A; Fernández-Cruz M.L; Fito C; Gómez-Ganau S; Gozalbes R; Hernández-Moreno D; de Julián-Ortiz J.V; Lombardo A; Marzo M; Ranero I; Ruiz-Costa N; Tarazona-Díez J.V; Benfenati E; (2021)
  Computational Tools for the Assessment and Substitution of Biocidal Active Substances of Ecotoxicological Concern: The LIFE-COMBASE Project
  Chemometrics and Cheminformatics in Aquatic Toxicology
  DOI: 10.1002/9781119681397.ch27
- Bermejo-Nogales A; Rucandio I; Connolly M; Fernández-Cruz M.L; Navas J.M; (2021)
  Preparation of feed with metal oxide nanoparticles for nanomaterial dietary exposure to fish and use in OECD TG 305
  MethodsX
  DOI: 10.1016/j.mex.2021.101413
- Amorim, M.J.B., Fernández-Cruz, M.L., Hund-Rinke, K., Scott-Fordsmand, J.J. (2020)
  Environmental hazard testing of nanobiomaterials
  Environmental Sciences Europe | 32
  DOI: 10.1186/s12302-020-00369-8
- Blázquez, M., Andreu-Sánchez, O., Ranero, I., Fernández-Cruz, M.L., Benfenati, E. (2020)
  Comparing in vivo data and in silico predictions for acute effects assessment of biocidal active substances and metabolites for aquatic organisms
  Ecotoxicology and Environmental Safety | 205
  DOI: 10.1016/j.ecoenv.2020.111291
- Sánchez Jiménez, A., Puelles, R., Pérez-Fernández, M., Gómez-Fernández, P., Barruetabeña, L., Jacobsen, N.R., Suarez-Merino, B., Micheletti, C., Manier, N., Trouiller, B., Navas, J.M., Kalman, J., Salieri, B., Hischier, R., Handzhiyski, Y., Apostolova, M.D., Hadrup, N., Bouillard, J., Oudart, Y., Merino, C., Garcia, E., Liguori, B., Sabella, S., Rose, J., Masion, A., Galea, K.S., Kelly, S., Štěpánková, S., Mouneyrac, C., Barrick, A., Châtel, A., Dusinska, M., Rundén-Pran, E., Mariussen, E., Bressot, C., Aguerre-Chariol, O., Shandilya, N., Goede, H., Gomez-Cordon, J., Simar, S., Nesslany, F., Jensen, K.A., van Tongeren, M., Rodríguez Llopis, I. (2020)
  Safe(r) by design implementation in the nanotechnology industry
  NanoImpact | 20
  DOI: 10.1016/j.impact.2020.100267
- Martínez-Gómez, C., Valdehita, A., Vethaak, A.D., Navas, J.M., León, V.M. (2020)
  Toxicity characterization of surface sediments from a Mediterranean coastal lagoon
  Chemosphere | 253
  DOI: 10.1016/j.chemosphere.2020.126710
- Hernández-Moreno, D., Morales, S., Camello-Almaraz, C., Pozo, M.J., Camello, P.J. (2020)
  Monochloramine effects on gallbladder contractility
  Clinical and Experimental Pharmacology and Physiology
  DOI: 10.1111/1440-1681.13453
- Spevakova, I., Fernandez-Cruz, M.-L., Tokarova, K., Greifova, H., Capcarova, M. (2020)
  The protective effect of stilbenes resveratrol and pterostilbene individually and combined with mycotoxin citrinin in human adenocarcinoma HT-29 cell line in vitro
  Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering | 56 : 75-88
  DOI: 10.1080/10934529.2020.1839279
- Hernández-Moreno, D., Valdehita, A., Conde, E., Rucandio, I., Navas, J.M., Fernández-Cruz, M.L. (2019)
  Acute toxic effects caused by the co-exposure of nanoparticles of ZnO and Cu in rainbow trout
  Science of the Total Environment | 687 : 24-33
  DOI: 10.1016/j.scitotenv.2019.06.084
- Barrick, A., Châtel, A., Manier, N., Kalman, J., Navas, J.M., Mouneyrac, C. (2019)
  Investigating the Impact of Manufacturing Processes on the Ecotoxicity of Carbon Nanofibers: A Multi–Aquatic Species Comparison
  Environmental Toxicology and Chemistry | 38 : 2314-2325
  DOI: 10.1002/etc.4537
- García-Herranz, V., Valdehita, A., Navas, J.M., Fernández-Cruz, M.L. (2019)
  Cytotoxicity against fish and mammalian cell lines and endocrine activity of the mycotoxins beauvericin, deoxynivalenol and ochratoxin-A
  Food and Chemical Toxicology | 127 : 288-297
  DOI: 10.1016/j.fct.2019.01.036
- Blázquez, M., Fernández-Cruz, M.L., Gajewicz, A., Puzyn, T., Benfenati, E. (2019)
  On the uses of predictive toxicology to approve the use of engineered nanomaterials as biocidal active substances under the Biocidal Products Regulation
  IOP Conference Series: Materials Science and Engineering | 499
  DOI: 10.1088/1757-899X/499/1/012007
- Giusti, A., Atluri, R., Tsekovska, R., Gajewicz, A., Apostolova, M.D., Battistelli, C.L., Bleeker, E.A.J., Bossa, C., Bouillard, J., Dusinska, M., Gómez-Fernández, P., Grafström, R., Gromelski, M., Handzhiyski, Y., Jacobsen, N.R., Jantunen, P., Jensen, K.A., Mech, A., Navas, J.M., Nymark, P., Oomen, A.G., Puzyn, T., Rasmussen, K., Riebeling, C., Rodriguez-Llopis, I., Sabella, S., Sintes, J.R., Suarez-Merino, B., Tanasescu, S., Wallin, H., Haase, A. (2019)
  Nanomaterial grouping: Existing approaches and future recommendations
  NanoImpact | 16
  DOI: 10.1016/j.impact.2019.100182
- Hernández-Moreno, D., Blázquez, M., Andreu-Sánchez, O., Bermejo-Nogales, A., Fernández-Cruz, M.L. (2019)
  Acute hazard of biocides for the aquatic environmental compartment from a life-cycle perspective
  Science of the Total Environment | 658 : 416-423
  DOI: 10.1016/j.scitotenv.2018.12.186
- Kalman, J., Merino, C., Fernández-Cruz, M.L., Navas, J.M. (2019)
  Usefulness of fish cell lines for the initial characterization of toxicity and cellular fate of graphene-related materials (carbon nanofibers and graphene oxide)
  Chemosphere | 218 : 347-358
  DOI: 10.1016/j.chemosphere.2018.11.130
- Vizuete, J., Hernández-Moreno, D., Fidalgo, L.E., Bertini, S., Andreini, R., Soler, F., Míguez-Santiyán, M.P., López-Beceiro, A., Pérez-López, M. (2018)
  Concentrations of chlorinated pollutants in adipose tissue of yellow-legged gulls (Larus michahellis) from Spain: Role of gender and age
  Ecotoxicology and Environmental Safety | 164 : 493-499
  DOI: 10.1016/j.ecoenv.2018.08.060
- Hernández-Moreno, D., Míguez, M.P., Soler, F., Pérez-López, M. (2018)
  Influence of sex on biomarkers of oxidative stress in the kidney, lungs, and liver of rabbits after exposure to diazinon
  Environmental Science and Pollution Research | 25 : 32458-32465
  DOI: 10.1007/s11356-018-3258-6
- Galbis-Martínez, L., Fernández-Cruz, M.L., Alte, L., Valdehita, A., Rucandio, I., Navas, J.M. (2018)
  Development of a new tool for the long term in vitro ecotoxicity testing of nanomaterials using a rainbow-trout cell line (RTL-W1)
  Toxicology in Vitro | 50 : 305-317
  DOI: 10.1016/j.tiv.2018.04.007
- Valcárcel, Y., Valdehíta, A., Becerra, E., López de Alda, M., Gil, A., Gorga, M., Petrovic, M., Barceló, D., Navas, J.M. (2018)
  Determining the presence of chemicals with suspected endocrine activity in drinking water from the Madrid region (Spain) and assessment of their estrogenic, androgenic and thyroidal activities
  Chemosphere | 201 : 388-398
  DOI: 10.1016/j.chemosphere.2018.02.099
- Furley, T.H., Brodeur, J., Silva de Assis, H.C., Carriquiriborde, P., Chagas, K.R., Corrales, J., Denadai, M., Fuchs, J., Mascarenhas, R., Miglioranza, K.S.B., Miguez Caramés, D.M., Navas, J.M., Nugegoda, D., Planes, E., Rodriguez-Jorquera, I.A., Orozco-Medina, M., Boxall, A.B.A., Rudd, M.A., Brooks, B.W. (2018)
  Toward sustainable environmental quality: Identifying priority research questions for Latin America
  Integrated Environmental Assessment and Management | 14 : 344-357
  DOI: 10.1002/ieam.2023
- Amorim, M.J.B., Lin, S., Schlich, K., Navas, J.M., Brunelli, A., Neubauer, N., Vilsmeier, K., Costa, A.L., Gondikas, A., Xia, T., Galbis, L., Badetti, E., Marcomini, A., Hristozov, D., Kammer, F.V.D., Hund-Rinke, K., Scott-Fordsmand, J.J., Nel, A., Wohlleben, W. (2018)
  Environmental Impacts by Fragments Released from Nanoenabled Products: A Multiassay, Multimaterial Exploration by the SUN Approach
  Environmental Science and Technology | 52 : 1514-1524
  DOI: 10.1021/acs.est.7b04122
- Calado, T., Fernández-Cruz, M.L., Cabo Verde, S., Venâncio, A., Abrunhosa, L. (2018)
  Gamma irradiation effects on ochratoxin A: Degradation, cytotoxicity and application in food
  Food Chemistry | 240 : 463-471
  DOI: 10.1016/j.foodchem.2017.07.136
- Pérez-Sánchez, J., Simó-Mirabet, P., Naya-Català, F., Martos-Sitcha, J.A., Perera, E., Bermejo-Nogales, A., Benedito-Palos, L., Calduch-Giner, J.A. (2018)
  Somatotropic axis regulation unravels the differential effects of nutritional and environmental factors in growth performance of marine farmed fishes
  Frontiers in Endocrinology | 9
  DOI: 10.3389/fendo.2018.00687
- Handy, R.D., Ahtiainen, J., Navas, J.M., Goss, G., Bleeker, E.A.J., Von Der Kammer, F. (2018)
  Proposal for a tiered dietary bioaccumulation testing strategy for engineered nanomaterials using fish
  Environmental Science: Nano | 5 : 2030-2046
  DOI: 10.1039/c7en01139c
- Scott-Fordsmand, J.J., Navas, J.M., Hund-Rinke, K., Nowack, B., Amorim, M.J.B. (2017)
  Nanomaterials to microplastics: Swings and roundabouts
  Nano Today | 17 : 7-10
  DOI: 10.1016/j.nantod.2017.09.002
- Bermejo-Nogales, A., Fernández-Cruz, M.L., Navas, J.M. (2017)
  Fish cell lines as a tool for the ecotoxicity assessment and ranking of engineered nanomaterials
  Regulatory Toxicology and Pharmacology | 90 : 297-307
  DOI: 10.1016/j.yrtph.2017.09.029
- Muñiz, S., Gonzalvo, P., Valdehita, A., Molina-Molina, J.M., Navas, J.M., Olea, N., Fernández-Cascán, J., Navarro, E. (2017)
  Ecotoxicological assessment of soils polluted with chemical waste from lindane production: Use of bacterial communities and earthworms as bioremediation tools
  Ecotoxicology and Environmental Safety | 145 : 539-548
  DOI: 10.1016/j.ecoenv.2017.07.070
- Habila, S., Leghouchi, E., Valdehita, A., Bermejo-Nogales, A., Khelili, S., Navas, J.M. (2017)
  Induction of EROD and BFCOD activities in tissues of barbel (Barbus callensis) from a water reservoir in Algeria
  Ecotoxicology and Environmental Safety | 142 : 129-138
  DOI: 10.1016/j.ecoenv.2017.03.055
- Martos-Sitcha, J.A., Bermejo-Nogales, A., Calduch-Giner, J.A., Pérez-Sánchez, J. (2017)
  Gene expression profiling of whole blood cells supports a more efficient mitochondrial respiration in hypoxia-challenged gilthead sea bream (Sparus aurata)
  Frontiers in Zoology | 14
  DOI: 10.1186/s12983-017-0220-2
- Valdehita, A., Fernández-Cruz, M.-L., González-Gullón, M.I., Becerra-Neira, E., Delgado, M.M., García-González, M.C., Navas, J.M. (2017)
  Androgens and androgenic activity in broiler manure assessed by means of chemical analyses and in vitro bioassays
  Environmental Toxicology and Chemistry | 36 : 1746-1754
  DOI: 10.1002/etc.3495
- Neila, C., Hernández-Moreno, D., Fidalgo, L.E., López-Beceiro, A., Soler, F., Pérez-López, M. (2017)
  Does gender influence the levels of heavy metals in liver of wild boar?
  Ecotoxicology and Environmental Safety | 140 : 24-29
  DOI: 10.1016/j.ecoenv.2017.02.025
- Bermejo-Nogales, A., Connolly, M., Rosenkranz, P., Fernández-Cruz, M.-L., Navas, J.M. (2017)
  Negligible cytotoxicity induced by different titanium dioxide nanoparticles in fish cell lines
  Ecotoxicology and Environmental Safety | 138 : 309-319
  DOI: 10.1016/j.ecoenv.2016.12.039
- Polloni-Silva, J., Valdehita, A., Fracácio, R., Navas, J.M. (2017)
  Remediation efficiency of three treatments on water polluted with endocrine disruptors: Assessment by means of in vitro techniques
  Chemosphere | 173 : 267-274
  DOI: 10.1016/j.chemosphere.2017.01.029
- Simó-Mirabet, P., Bermejo-Nogales, A., Calduch-Giner, J.A., Pérez-Sánchez, J. (2017)
  Tissue-specific gene expression and fasting regulation of sirtuin family in gilthead sea bream (Sparus aurata)
  Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology | 187 : 153-163
  DOI: 10.1007/s00360-016-1014-0
- Bermejo-Nogales, A., Fernández, M., Fernández-Cruz, M.L., Navas, J.M. (2016)
  Effects of a silver nanomaterial on cellular organelles and time course of oxidative stress in a fish cell line (PLHC-1)
  Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology | 190 : 54-65
  DOI: 10.1016/j.cbpc.2016.08.004
- Pasanisi, E., Cortés-Gómez, A.A., Pérez-López, M., Soler, F., Hernández-Moreno, D., Guerranti, C., Martellini, T., Fuentes-Mascorro, G., Romero, D., Cincinelli, A. (2016)
  Levels of perfluorinated acids (PFCAs) in different tissues of Lepidochelys olivacea sea turtles from the Escobilla beach (Oaxaca, Mexico)
  Science of the Total Environment | 572 : 1059-1065
  DOI: 10.1016/j.scitotenv.2016.08.013
- Hund-Rinke, K., Baun, A., Cupi, D., Fernandes, T.F., Handy, R., Kinross, J.H., Navas, J.M., Peijnenburg, W., Schlich, K., Shaw, B.J., Scott-Fordsmand, J.J. (2016)
  Regulatory ecotoxicity testing of nanomaterials–proposed modifications of OECD test guidelines based on laboratory experience with silver and titanium dioxide nanoparticles
  Nanotoxicology | 10 : 1442-1447
  DOI: 10.1080/17435390.2016.1229517
- Fernández-Cruz, M.L., Martín-Cabrejas, I., Pérez-del Palacio, J., Gaya, P., Díaz-Navarro, C., Navas, J.M., Medina, M., Arqués, J.L. (2016)
  In vitro toxicity of reuterin, a potential food biopreservative
  Food and Chemical Toxicology | 96 : 155-159
  DOI: 10.1016/j.fct.2016.08.002
- Hernández-Moreno, D., Li, L., Connolly, M., Conde, E., Fernández, M., Schuster, M., Navas, J.M., Fernández-Cruz, M.-L. (2016)
  Mechanisms underlying the enhancement of toxicity caused by the coincubation of zinc oxide and copper nanoparticles in a fish hepatoma cell line
  Environmental Toxicology and Chemistry | 35 : 2562-2570
  DOI: 10.1002/etc.3425
- Quesada-García, A., Encinas, P., Valdehita, A., Baumann, L., Segner, H., Coll, J.M., Navas, J.M. (2016)
  Thyroid active agents T3 and PTU differentially affect immune gene transcripts in the head kidney of rainbow trout (Oncorynchus mykiss)
  Aquatic Toxicology | 174 : 159-168
  DOI: 10.1016/j.aquatox.2016.02.016
- Cano-Sancho, G., González-Arias, C.A., Ramos, A.J., Sanchis, V., Fernández-Cruz, M.L. (2015)
  Cytotoxicity of the mycotoxins deoxynivalenol and ochratoxin A on Caco-2 cell line in presence of resveratrol
  Toxicology in Vitro | 29 : 1639-1646
  DOI: 10.1016/j.tiv.2015.06.020
- Lammel, T., Boisseaux, P., Navas, J.M. (2015)
  Potentiating effect of graphene nanomaterials on aromatic environmental pollutant-induced cytochrome P450 1A expression in the topminnow fish hepatoma cell line PLHC-1
  Environmental Toxicology | 30 : 1192-1204
  DOI: 10.1002/tox.21991
- Connolly, M., Fernandez-Cruz, M.-L., Quesada-Garcia, A., Alte, L., Segner, H., Navas, J.M. (2015)
  Comparative cytotoxicity study of silver nanoparticles (Agnps) in a variety of rainbow trout cell lines (RTL-W1, RTH-149, RTG-2) and primary hepatocytes
  International Journal of Environmental Research and Public Health | 12 : 5386-5405
  DOI: 10.3390/ijerph120505386
- Quesada-García, A., Valdehita, A., Del Olmo, I., Gómez, M.J., Navas, J.M. (2015)
  Detection of Effects Caused by Very Low Levels of Contaminants in Riverine Sediments Through a Combination of Chemical Analysis, in Vitro Bioassays, and Farmed Fish as Sentinel
  Archives of Environmental Contamination and Toxicology | 68 : 663-677
  DOI: 10.1007/s00244-014-0127-2
- Bermejo-Nogales, A., Calduch-Giner, J.A., Pérez-Sánchez, J. (2015)
  Unraveling the molecular signatures of oxidative phosphorylation to cope with the nutritionally changing metabolic capabilities of liver and muscle tissues in farmed fish
  PLoS ONE | 10
  DOI: 10.1371/journal.pone.0122889
- Connolly, M., Fernández-Cruz, M.L., Navas, J.M. (2015)
  Recovery of redox homeostasis altered by CuNPs in H4IIE liver cells does not reduce the cytotoxic effects of these NPs: An investigation using aryl hydrocarbon receptor (AhR) dependent antioxidant activity
  Chemico-Biological Interactions | 228 : 57-68
  DOI: 10.1016/j.cbi.2015.01.012
- Li, L., Fernández-Cruz, M.L., Connolly, M., Conde, E., Fernández, M., Schuster, M., Navas, J.M. (2015)
  The potentiation effect makes the difference: Non-toxic concentrations of ZnO nanoparticles enhance Cu nanoparticle toxicity in vitro
  Science of the Total Environment | 505 : 253-260
  DOI: 10.1016/j.scitotenv.2014.10.020
- Li, L., Fernández-Cruz, M.L., Connolly, M., Schuster, M., Navas, J.M. (2015)
  Dissolution and aggregation of Cu nanoparticles in culture media: effects of incubation temperature and particles size
  Journal of Nanoparticle Research | 17
  DOI: 10.1007/s11051-015-2865-0
- Mary, V.S., Valdehita, A., Navas, J.M., Rubinstein, H.R., Fernández-Cruz, M.L. (2015)
  Effects of aflatoxin B1, fumonisin B1 and their mixture on the aryl hydrocarbon receptor and cytochrome P450 1A induction
  Food and Chemical Toxicology | 75 : 104-111
  DOI: 10.1016/j.fct.2014.10.030
- Song, L., Connolly, M., Fernández-Cruz, M.L., Vijver, M.G., Fernández, M., Conde, E., De Snoo, G.R., Peijnenburg, W.J.G.M., Navas, J.M. (2014)
  Species-specific toxicity of copper nanoparticles among mammalian and piscine cell lines
  Nanotoxicology | 8 : 383-393
  DOI: 10.3109/17435390.2013.790997
- Lammel, T., Navas, J.M. (2014)
  Graphene nanoplatelets spontaneously translocate into the cytosol and physically interact with cellular organelles in the fish cell line PLHC-1
  Aquatic Toxicology | 150 : 55-65
  DOI: 10.1016/j.aquatox.2014.02.016
- De La Casa-Resino, I., Navas, J.M., Fernández-Cruz, M.L. (2014)
  Chlorotriazines do not activate the aryl hydrocarbon receptor, the oestrogen receptor or the thyroid receptor in in vitro assays
  ATLA Alternatives to Laboratory Animals | 42 : 25-30
  DOI: 10.1177/026119291404200105
- Quesada-García, A., Valdehita, A., Kropf, C., Casanova-Nakayama, A., Segner, H., Navas, J.M. (2014)
  Thyroid signaling in immune organs and cells of the teleost fish rainbow trout (Oncorhynchus mykiss)
  Fish and Shellfish Immunology | 38 : 166-174
  DOI: 10.1016/j.fsi.2014.03.016
- Oliveira, E., Casado, M., Faria, M., Soares, A.M.V.M., Navas, J.M., Barata, C., Piña, B. (2014)
  Transcriptomic response of zebrafish embryos to polyaminoamine (PAMAM) dendrimers
  Nanotoxicology | 8 : 92-99
  DOI: 10.3109/17435390.2013.858376
- Tetko, I.V., Schramm, K.-W., Knepper, T., Peijnenburg, W.J.G.M., Hendriks, A.J., Navas, J.M., Nicholls, I.A., Öberg, T., Todeschini, R., Schlosser, E., Brandmaier, S. (2014)
  Experimental and theoretical studies in the EU FP7 Marie Curie initial training network project, environmental chemoinformatics (ECO)
  ATLA Alternatives to Laboratory Animals | 42 : 7-11
  DOI: 10.1177/026119291404200103
- Scholz, S., Sela, E., Blaha, L., Braunbeck, T., Galay-Burgos, M., García-Franco, M., Guinea, J., Klüver, N., Schirmer, K., Tanneberger, K., Tobor-Kapłon, M., Witters, H., Belanger, S., Benfenati, E., Creton, S., Cronin, M.T.D., Eggen, R.I.L., Embry, M., Ekman, D., Gourmelon, A., Halder, M., Hardy, B., Hartung, T., Hubesch, B., Jungmann, D., Lampi, M.A., Lee, L., Léonard, M., Küster, E., Lillicrap, A., Luckenbach, T., Murk, A.J., Navas, J.M., Peijnenburg, W., Repetto, G., Salinas, E., Schüürmann, G., Spielmann, H., Tollefsen, K.E., Walter-Rohde, S., Whale, G., Wheeler, J.R., Winter, M.J. (2013)
  A European perspective on alternatives to animal testing for environmental hazard identification and risk assessment
  Regulatory Toxicology and Pharmacology | 67 : 506-530
  DOI: 10.1016/j.yrtph.2013.10.003
- De La Casa-Resino, I., Hernández-Moreno, D., Navas, J.M., Soler, F., Pérez-López, M. (2013)
  Non-destructive multibiomarker approach in European quail (Coturnix coturnix coturnix) exposed to the herbicide atrazine
  Archives of Environmental Contamination and Toxicology | 65 : 567-574
  DOI: 10.1007/s00244-013-9907-3
- Fernández-Cruz, M.L., Lammel, T., Connolly, M., Conde, E., Barrado, A.I., Derick, S., Perez, Y., Fernandez, M., Furger, C., Navas, J.M. (2013)
  Comparative cytotoxicity induced by bulk and nanoparticulated ZnO in the fish and human hepatoma cell lines PLHC-1 and Hep G2
  Nanotoxicology | 7 : 935-952
  DOI: 10.3109/17435390.2012.676098
- Cockburn, A., Brambilla, G., Fernández-Cruz, M.L., Arcella, D., Bordajandi, L.R., Cottrill, B., van Peteghem, C., Dorne, J.-L. (2013)
  Nitrite in feed: From animal health to human health
  Toxicology and Applied Pharmacology | 270 : 209-217
  DOI: 10.1016/j.taap.2010.11.008
- Dorne, J.L.C.M., Fernández-Cruz, M.L., Bertelsen, U., Renshaw, D.W., Peltonen, K., Anadon, A., Feil, A., Sanders, P., Wester, P., Fink-Gremmels, J. (2013)
  Risk assessment of coccidostatics during feed cross-contamination: Animal and human health aspects
  Toxicology and Applied Pharmacology | 270 : 196-208
  DOI: 10.1016/j.taap.2010.12.014
- Lammel, T., Boisseaux, P., Fernández-Cruz, M.-L., Navas, J.M. (2013)
  Internalization and cytotoxicity of graphene oxide and carboxyl graphene nanoplatelets in the human hepatocellular carcinoma cell line Hep G2
  Particle and Fibre Toxicology | 10
  DOI: 10.1186/1743-8977-10-27
- Malhão, F., Urbatzka, R., Navas, J.M., Cruzeiro, C., Monteiro, R.A.F., Rocha, E. (2013)
  Cytological, immunocytochemical, ultrastructural and growth characterization of the rainbow trout liver cell line RTL-W1
  Tissue and Cell | 45 : 159-174
  DOI: 10.1016/j.tice.2012.10.006
- Connolly, M., Pérez, Y., Mann, E., Herradón, B., Fernández-Cruz, M.L., Navas, J.M. (2013)
  Peptide-biphenyl hybrid-capped AuNPs: Stability and biocompatibility under cell culture conditions
  Nanoscale Research Letters | 8 : 1-21
  DOI: 10.1186/1556-276X-8-315
- Mezcua, M., Martínez-Uroz, M.A., Gómez-Ramos, M.M., Gómez, M.J., Navas, J.M., Fernández-Alba, A.R. (2012)
  Analysis of synthetic endocrine-disrupting chemicals in food: A review
  Talanta | 100 : 90-106
  DOI: 10.1016/j.talanta.2012.07.078
- Rosenkranz, P., Fernández-Cruz, M.L., Conde, E., Ramírez-Fernández, M.B., Flores, J.C., Fernández, M., Navas, J.M. (2012)
  Effects of cerium oxide nanoparticles to fish and mammalian cell lines: An assessment of cytotoxicity and methodology
  Toxicology in Vitro | 26 : 888-896
  DOI: 10.1016/j.tiv.2012.04.019
- Valdehita, A., Fernández-Cruz, M.L., Torrent, F., Sericano, J.L., Navas, J.M. (2012)
  Differences in the induction of cyp1A and related genes in cultured rainbow trout Oncorhynchus mykiss. Additional considerations for the use of EROD activity as a biomarker
  Journal of Fish Biology | 81 : 270-287
  DOI: 10.1111/j.1095-8649.2012.03338.x
- Raldúa, D., Barata, C., Casado, M., Faria, M., Navas, J.M., Olivares, A., Oliveira, E., Pelayo, S., Thienpont, B., Piña, B. (2012)
  Zebrafish as a Vertebrate Model to Assess Sublethal Effects and Health Risks of Emerging Pollutants
  Handbook of Environmental Chemistry | 20 : 395-414
  DOI: 10.1007/698_2011_124
- De La Casa-Resino, I., Valdehita, A., Soler, F., Navas, J.M., Pérez-López, M. (2012)
  Endocrine disruption caused by oral administration of atrazine in European quail (Coturnix coturnix coturnix)
  Comparative Biochemistry and Physiology - C Toxicology and Pharmacology | 156 : 159-165
  DOI: 10.1016/j.cbpc.2012.07.006
- Fernández-Cruz, M.L., Valdehita, A., Alonso, M., Mann, E., Herradón, B., Navas, J.M. (2011)
  Biological and chemical studies on aryl hydrocarbon receptor induction by the p53 inhibitor pifithrin-α and its condensation product pifithrin-β
  Life Sciences | 88 : 774-783
  DOI: 10.1016/j.lfs.2011.02.019
- Bosch, C., Olivares, A., Faria, M., Navas, J.M., del Olmo, I., Grimalt, J.O., Piña, B., Barata, C. (2009)
  Identification of water soluble and particle bound compounds causing sublethal toxic effects. A field study on sediments affected by a chlor-alkali industry
  Aquatic Toxicology | 94 : 16-27
  DOI: 10.1016/j.aquatox.2009.05.011
- Navas, J.M., Segner, H. (2008)
  In-vitro screening of the antiestrogenic activity of chemicals
  Expert Opinion on Drug Metabolism and Toxicology | 4 : 605-617
  DOI: 10.1517/17425255.4.5.605
- Alonso, M., Casado, S., Miranda, C., Tarazona, J.V., Navas, J.M., Herradón, B. (2008)
  Decabromobiphenyl (PBB-209) activates the aryl hydrocarbon receptor while decachlorobiphenyl (PCB-209) is inactive: Experimental evidence and computational rationalization of the different behavior of some halogenated biphenyls
  Chemical Research in Toxicology | 21 : 643-658
  DOI: 10.1021/tx700362u
- Jos, A., Segner, H., Herradón, B., Repetto, G., Navas, J.M. (2007)
  Induction of EROD activity by 1-phenylimidazole and β-naphthoflavone in rainbow trout cultured hepatocytes: A comparative study
  Toxicology in Vitro | 21 : 1307-1310
  DOI: 10.1016/j.tiv.2007.03.017
- Boronat, S., Casado, S., Navas, J.M., Piña, B. (2007)
  Modulation of aryl hydrocarbon receptor transactivation by carbaryl, a nonconventional ligand
  FEBS Journal | 274 : 3327-3339
  DOI: 10.1111/j.1742-4658.2007.05867.x
- Navas, J.M., Segner, H. (2006)
  Vitellogenin synthesis in primary cultures of fish liver cells as endpoint for in vitro screening of the (anti)estrogenic activity of chemical substances
  Aquatic Toxicology | 80 : 1-22
  DOI: 10.1016/j.aquatox.2006.07.013
- Fernández-Cruz, M.L., Barreda, M., Villarroya, M., Peruga, A., Llanos, S., García-Baudín, J.M. (2006)
  Captan and fenitrothion dissipation in field-treated cauliflowers and effect of household processing
  Pest Management Science | 62 : 637-645
  DOI: 10.1002/ps.1217
- Fernández-Cruz, M.L., Grimalt, S., Villarroya, M., López, F.J., Llanos, S., García-Baudín, J.M. (2006)
  Residue levels of captan and trichlorfon in field-treated kaki fruits, individual versus composite samples, and after household processing
  Food Additives and Contaminants | 23 : 591-600
  DOI: 10.1080/02652030500529460

Maria Luisa Fernández Cruz y David Hernández Moreno
MicoMixFishFeed: Riesgos de exposición prolongada a mezclas de micotoxinas presentes en piensos para peces.
2022 - 2025
José María Navas
Advanced High Aspect Ratio and Multicomponent materials: towards comprehensive intelLigent tEsting and Safe by design Strategies
2021 - 2025
José María Navas
A INIA para la realización de trabajos sobre productos químicos y nanomateriales
2021 - 2024
David Hernández Moreno y Azucena Bermejo Nogales
Protocolo para la evaluación de compuestos alternativos al uso de rodenticidas anticoagulantes
2022 - 2024
Maria Luisa Fernández Cruz
Toxicity of nanomaterials (NMs) against fish and implementation of OECD TG 249 for NMs
2022 - 2024
HELMHOLTZ ZENTRUM MUENCHEN HMGU, Alemania; ) & José María Navas.
HARMLESS. Advanced High Aspect Ratio and Multicomponent materials: towards comprehensive intelLigent tEsting and Safe by design Strategies.
2020 - 2024
Azucena Bermejo Nogales
Identificación de rutas alternativas implicadas en la resistencia a rodenticidas
2022 - 2023
David Hernández Moreno
Evaluación de efectos tóxicos mediante el uso de métodos alternativos: ensayos con embriones de pez cebra
2022 - 2023
Azucena Bermejo Nogales
Caracterización de mutaciones relacionadas con resistencias a rodenticidas en España e incidencia en poblaciones de roedores.
2020 - 2023
José María Navas
Graphene Flagship Core Project 3
2020 - 2023
Maria Luisa Fernández Cruz
Towards harmonised test methods for nanomaterials
2020 - 2023
Thomas Kuhlbusch (BAUA, Germany) & María Luisa Fernández
NanoHarmony “Towards harmonised test methods for nanomaterials” (H2020 Grant Agreement 885931). European Comission.14 participants.
2020 - 2023
José María Navas
Graphene-Core 3 (EU H2020, Grant Agreement 785219)
2020 - 2023
María Luisa Fernández Cruz
H2020 Project GOV4NANO “Implementation of Risk Governance: meeting the needs of nanotechnology”
2019 - 2022
María Luisa Fernández-Cruz
“Use of nanotechnology to reduce the contamination by mycotoxins in fish feed”
2017 - 2021
María Luisa Fernández-Cruz
H2020 Project BIORIMA “BIOmaterial RIsk MAnagement”
2017 - 2021
José María Navas
Graphene Flagship Programme “Graphene-Core 2”
2018 - 2020
José María Navas
H2020 Project-MSCA-IF-2016. “Spheroids as a Tool to Assess Realistic long term effects of mixtures of nanomaterials and chemicals (STARNANO)”. February 2018-January 2020.
2018 - 2020
María Luisa Fernández Cruz
LIFE-COMBASE “Computational tool for the assessment and substitution of Biocidal Active Substances of Ecotoxicological concern”
2016 - 2019
José María Navas
H2020 Project NanoReg2. “Development and implementation Grouping and Safe-by-Design approaches within regulatory frameworks”
2015 - 1899
María Luisa Fernández Cruz
FP7 Project GUIDEnano. “Assessment and mitigation of nano-enabled product risks on human and environmental health: Development of new strategies and creation of a digital guidance tool for nanotech industries"
2013 - 1899
José María Navas
FP7 Project SUN. “Sustainable Nanotechnologies”
2013 - 1899
José María Navas
National Project: “Endocrine disruption and toxic effects related to the presence of hormones, antibiotics, mycotoxins and other substances in farm residues”
2013 - 1899
José María Navas
FP7 Project MARINA. Managing Risks of Nanomaterials.
2011 - 1899
José María Navas
FP7 People. Marie-Curie. Initial Training Network (ITN). “ECO. Environmental ChemOinformatics”.
2009 - 1899
María Luisa Fernández-Cruz
“Scientific cooperation for the search of strategies of control and prevention of mycotoxins in agricultural production”. CYTED IBEROAMERICA. July 2011
2011 - 1899
José María Navas
“Endocrine disruption related to farm residues”.
2009 - 1899
María Luisa Fernández-Cruz
Agreement EG17-017 between INIA and the General Direction of Environment Quality and Evaluation related to Substances y chemical mixtures: environmenatl risk assessment, identification of endocrine disruptors and nanomaterials and uses control
2017 - 1899
José María Navas y María Luisa Fernández Cruz
Agreement EG13-074 between INIA and the General Direction of Environment Quality and Evaluation for the environmental risk assessment of substances and chemical products according to the National and European regulations
2013 - 1899
José María Navas
Agreement AEG07-060 between INIA and the Ministry of Environment to aply the REACH Regulation and related rules including those of Biocides and Plant Protection Products
2009 - 1899
José María Navas
Agreement AEG09-036 between INIA and the Ministry of Environment for the national implementation and application of the Stockholm Convention and the regulation 850/2004/CE about Persistent Organic Pollutants (POPs)
2009 - 1899

Jorge Vizuete Zorita (2023)
Evaluación de la utilidad de la gaviota patiamarilla (Larus michahellis) en estudios de contaminación ambiental: análisis de contaminantes ambientales y biomarcadores.
Dirección: David Hernández Moreno y María Prado Míguez Santillán | Universidad de Extremadura
Victor García Herranz (2022)
Interacción entre el receptor de hormonas tiroideas y contaminantes presentes en gallinaza
Dirección: María Luisa Fernández Cruz y José María Navas | Universidad Autónoma de Madrid
Sasana Casado
Mechanisms of activation of the aryl hydrocarbon receptor in fish
Dirección: José María Navas | Universidad Complutense de Madrid (UCM).
Tobias Lammel
New insights into the toxicity of nanomaterials obtained by means of fish and mammalian cell lines
Dirección: José María Navas | Universidad Autónoma de Madrid
Irene de la Casa Resino
Nuevos horizontes en Ecotoxicología: biomarcadores destructivos y no destructivos en codorniz (Coturnix coturnix) y cigüeña blanca (Ciconia ciconia).
Dirección: Marcos Pérez López, Francisco Soler Rodríguez y José María Navas | Universidad de Extremadura
Alba Quesada García
Expression and function of detoxification processes in fish and alterations of reproductive hormonal regulation
Dirección: José María Navas y Ana Valdehita | Universidad Autónoma de Madrid
Mona Connolly
Mechanisms underlying the toxic action of nanomaterials: in vitro and in vivo approaches
Dirección: José María Navas y María Luisa Fernández Cruz | Universidad Complutense de Madrid
Victor García Herranz
Thyroidal activity in manure. Determination of responsible substances
Dirección: José María Navas y María Luisa Fernández Cruz | Universidad Autónoma de Madrid