Titulo de la pagina
Efectos de Contaminantes Ambientales

Nuestro objetivo principal es estudiar los mecanismos subyacentes a la toxicidad de contaminantes emergentes (e.g. nanomateriales, disruptores endocrinos, biocidas o micotoxinas) y su bioacumulación en organismos acuáticos, particularmente en peces, mediante aproximaciones in vitro e in vivo. Además, desarrollamos metodologías de evaluación del riesgo medioambiental y estudiamos posibles resistencias a estos contaminantes.

Grupo de investigación dependiente del

Departamento de Medio Ambiente y Agronomía

La contaminación de los cursos de agua supone una grave amenaza para los ecosistemas y para la salud humana. Una de las principales fuentes de contaminación es el sector agroalimentario, en particular las prácticas agrícolas intensivas en las que se requiere el uso de sustancias químicas o nanomateriales que pueden producir efectos nocivos en los organismos acuáticos y en el ser humano. Nuestro grupo de investigación centra su trabajo en el estudio de la toxicidad de contaminantes, su bioacumulación y las alteraciones endocrinas que pueden causar sobre los organismos acuáticos. Estudiamos fundamentalmente los efectos de:

Nanomateriales
Residuos Agroalimentarios
Micotoxinas
Biocidas

El objetivo final es generar información y desarrollar las herramientas necesarias para evaluar los peligros de estas sustancias para el medioambiente y el ser humano. El conocimiento generado permite realizar diagnósticos del estado ambiental de áreas concretas, lo utilizan las agencias reguladoras para desarrollar herramientas de evaluación del riesgo y la industria para diseñar sistemas de producción y productos seguros.

Investigación

Nanomateriales

Los nanomateriales (NMs) son partículas con al menos una de sus dimensiones entre 1 nm y 100 nm. Poseen una elevada superficie con respecto a su volumen lo que les confiere propiedades muy particulares por lo que se están introduciendo de manera exponencial en el mercado para usos en diferentes sectores incluyendo el agroalimentario. Sin embargo, el conocimiento sobre sus efectos adversos es muy limitado.

Nuestros estudios han permitido determinar que los NMs: a) son tóxicos para las células de peces y para los organismos acuáticos en mayor o menor medida, dependiendo fundamentalmente de su naturaleza química y ejerciendo mecanismos de toxicidad específicos; b) son capaces de internalizarse en la célula acumulándose en diferentes orgánulos según su naturaleza; c) son absorbidos por los peces, distribuyéndose a diferentes órganos y bioacumulándose según el tipo de NM; d) pueden interaccionar entre sí produciendo efectos tóxicos más pronunciados (sinérgicos).

Residuos agroalimentarios

Hemos estudiado en detalle la actividad de disrupción endocrina (actividad estrogénica, androgénica y tiroidea) de residuos de gallinaza y purines. Hemos observado una carga hormonal importante, relacionada fundamentalmente con la presencia de hormonas naturales, de modo que la aplicación prolongada de estos residuos como enmienda agrícola puede causar efectos nocivos en los suelos y afectar a las aguas subterráneas.

Micotoxinas

Las micotoxinas son metabolitos secundarios de hongos filamentosos que contaminan productos vegetales y que presentan elevada toxicidad. La introducción reciente de las harinas vegetales en piensos para peces puede suponer un riesgo para los peces y para el consumidor. Hemos caracterizado in vitro la toxicidad y el efecto hormonal de varias micotoxinas y estamos estudiando estrategias para bloquear el efecto tóxico de estas sustancias naturales.

Biocidas

El uso de biocidas para el control de organismos nocivos está muy extendido por lo que su presencia en el medio acuático es conocida. Presentan una elevada toxicidad para los organismos acuáticos pero se desconoce el efecto tóxico de la mayoría de sus metabolitos. Hemos generado una herramienta in silico predictiva de la toxicidad de estas sustancias en algas, dafnias, peces y microorganismos. También hemos observado que los estudios de toxicidad en células de pez permiten predecir satisfactoriamente la toxicidad en peces.

También estamos estudiando la aparición de resistencias a rodenticidas anticoagulantes en poblaciones de roedores de toda España.

Miembros

Judit Kalman, Mona Connolly, Fazel Abdolahpur-Monikh, Rocío Fernández-Saavedra, Ana I Cardona-García, Estefanía Conde-Vilda, Salome Martínez-Morcillo, Willie J G M Peijnenburg, Isabel Rucandio, María Luisa Fernández-Cruz (2023)
Bioaccumulation of CuO nanomaterials in rainbow trout: Influence of exposure route and particle shape
Chemosphere | 310
DOI: 10.1016/j.chemosphere.2022.136894
Connolly M, Martínez-Morcillo S, Kalman J, Navas JM, Bleeker E, Fernández-Cruz ML (2023)
Considerations for bioaccumulation studies in fish with nanomaterials
Chemosphere | 312
DOI: 10.1016/j.chemosphere.2022.137299
Corredor-Santamaría, W., Calderón-Delgado, I.C., Arbeli, Z., Navas, J.M., Velasco-Santamaría, Y.M. (2023)
Acute effects on hepatic biomarkers in the freshwater native fish Aequidens metae exposed to polycyclic aromatic hydrocarbons
Global Journal of Environmental Science and Management | 9 : 1-14
DOI: 10.22034/gjesm.2023.01.01
Vizuete J., Pérez-López M, López-Beceiro A., Fidalgo L.E., Soler F., Míguez-Santiyán M.P., Hernández-Moreno D. (2023)
Biochemical Effects of Heavy Metals and Organochlorine Compounds Accumulated in Different Tissues of Yellow-Legged Gulls (Larus Michahellis)
Bulletin of Environmental Contamination and Toxicology | 110
DOI: 10.1007/s00128-023-03729-1
Hernández-Moreno, D., Blázquez, M., Navas, J.M., Fernández-Cruz, M.L. (2022)
Fish cell lines as screening tools to predict acute toxicity to fish of biocidal active substances and their relevant environmental metabolite
Aquatic Toxicology | 242
DOI: 10.1016/j.aquatox.2021.106020
Connolly, M., Hernández-Moreno, D., Conde, E., Garnica, A., Navas, J.M., Torrent, F., Rucandio, I., Fernández-Cruz, M.L. (2022)
Influence of citrate and PEG coatings on the bioaccumulation of TiO2 and CeO2 nanoparticles following dietary exposure in rainbow trout.
Environmental Sciences Europe | 34
DOI: 10.1186/s12302-021-00581-0
Beatriz Albero, Mª Luisa Fernández Cruz, Rosa Ana Pérez, (2022)
Simultaneous Determination of 15 Mycotoxins in Aquaculture Feed by Liquid Chromatography–Tandem Mass Spectrometry
Toxins | 14
DOI: 10.3390/toxins14050316
Vizuete, J., Hernández-Moreno, D., López-Beceiro, A., Fidalgo, L.E., Soler, F., Pérez-López, M., Míguez-Santiyán, M.P. (2022)
Heavy metals and metalloid levels in the tissues of yellow-legged gulls (Larus michahellis) from Spain: sex, age and geographical location differences.
Environmental Science and Pollution Research | 29 : 54292-54308
DOI: 10.1007/s11356-022-19627-8
Hernández-Moreno, D., Navas, J.M., Fernández-Cruz, M.L. (2022)
Short and long-term effects of nanobiomaterials in fish cell lines. Applicability of RTgill-W1
Chemosphere | 309
DOI: 10.1016/j.chemosphere.2022.136636
Bermejo-Nogales A; Rodríguez Martín J.A; Coll J; Navas J.M; (2022)
VKORC1 single nucleotide polymorphisms in rodents in Spain
Chemosphere
DOI: 10.1016/j.chemosphere.2022.136021
Badetti E; Brunelli A; Faraggiana E; Kalman J; Bettiol C; Izzo F.C; Navas J.M; Marcomini A; (2022)
Cytotoxicity inhibition of catechol's type molecules by grafting on TiO2 and Fe2O3 nanoparticles surface
Aquatic Toxicology
DOI: 10.1016/j.aquatox.2022.106291
Kalman J; Torrent F; Navas J.M; (2022)
Cytotoxicity of three graphene-related materials in rainbow trout primary hepatocytes is not associated to cellular internalization
Ecotoxicology and Environmental Safety
DOI: 10.1016/j.ecoenv.2022.113227
M Connolly, G Moles, F Candotto Carniel, M Tretiach, G Caorsi, E Flahaut, B Soula, E Pinelli, L Gauthier, F Mouchet, J M Navas (2022)
Applicability of OECD TG 201, 202, 203 for the aquatic toxicity testing and assessment of 2D Graphene material nanoforms to meet regulatory needs
NanoImpact | 29
DOI: 10.1016/j.impact.2022.100447
Ibarra, D., Martín-Sampedro, R., Wicklein, B., Borrero-López, A.M., Valencia, C., Valdehíta, A., Navas, J.M., Eugenio, M.E. (2022)
Populus alba L., an autochthonous species of spain: A source for cellulose nanofibers by chemical pretreatment
Polymers | 14
DOI: 10.3390/polym14010068
Hund-Rinke, K., Diaz, C., Jurack, A., Klein, J., Knopf, B., Schlich, K., Fernández-Cruz, M.L., Hernández-Moreno, D., Manier, N., Pandard, P., Gomes, S.I.L., Guimarães, B., Scott-Fordsmande, J.J., Amorim, M.J.B. (2021)
Nanopharmaceuticals (Au-NPs) and regulation after use: Experiences with a complex higher tier test design simulating environmental fate and effect
Ecotoxicology and Environmental Safety | 227
DOI: 10.1016/j.ecoenv.2021.112949
Hernández-Moreno, D., Ramos Martínez, A., Romay Cousido, C.M., Fidalgo, L.E., Menozzi, A., Bertini, S. (2021)
Heavy metals content in Great Shearwater (Ardenna gravis): accumulation, distribution and biomarkers of effect in different tissues.
Archives of Environmental Contamination and Toxicology | 80 : 615-623
DOI: 10.1007/s00244-021-00828-0
Bernal-Algaba E; Pulgarín-Alfaro M; Fernández-Cruz M.L; (2021)
Cytotoxicity of mycotoxins frequently present in aquafeeds to the fish cell line rtgill-w1
Toxins
DOI: 10.3390/toxins13080581
Corredor-Santamaría W; Mora-Solarte D.A; Arbeli Z; Navas J.M; Velasco-Santamaría Y.M; (2021)
Liver biomarkers response of the neotropical fish Aequidens metae to environmental stressors associated with the oil industry
Heliyon
DOI: 10.1016/j.heliyon.2021.e07458
Jeliazkova N; Apostolova M.D; Andreoli C; Barone F; Barrick A; Battistelli C; Bossa C; Botea-Petcu A; Châtel A; De Angelis I; Dusinska M; El Yamani N; Gheorghe D; Giusti A; Gómez-Fernández P; Grafström R; Gromelski M; Jacobsen N.R; Jeliazkov V; Jensen K.A; Kochev N; Kohonen P; Manier N; Mariussen E; Mech A; Navas J.M; Paskaleva V; Precupas A; Puzyn T; Rasmussen K; Ritchie P; Llopis I.R; Rundén-Pran E; Sandu R; Shandilya N; Tanasescu S; Haase A; Nymark P; (2021)
Towards FAIR nanosafety data
Nature Nanotechnology
DOI: 10.1038/s41565-021-00911-6
Blázquez M; Andreu-Sánchez O; Ballesteros A; Fernández-Cruz M.L; Fito C; Gómez-Ganau S; Gozalbes R; Hernández-Moreno D; de Julián-Ortiz J.V; Lombardo A; Marzo M; Ranero I; Ruiz-Costa N; Tarazona-Díez J.V; Benfenati E; (2021)
Computational Tools for the Assessment and Substitution of Biocidal Active Substances of Ecotoxicological Concern: The LIFE-COMBASE Project
Chemometrics and Cheminformatics in Aquatic Toxicology
DOI: 10.1002/9781119681397.ch27
Bermejo-Nogales A; Rucandio I; Connolly M; Fernández-Cruz M.L; Navas J.M; (2021)
Preparation of feed with metal oxide nanoparticles for nanomaterial dietary exposure to fish and use in OECD TG 305
MethodsX
DOI: 10.1016/j.mex.2021.101413
Amorim, M.J.B., Fernández-Cruz, M.L., Hund-Rinke, K., Scott-Fordsmand, J.J. (2020)
Environmental hazard testing of nanobiomaterials
Environmental Sciences Europe | 32
DOI: 10.1186/s12302-020-00369-8
Blázquez, M., Andreu-Sánchez, O., Ranero, I., Fernández-Cruz, M.L., Benfenati, E. (2020)
Comparing in vivo data and in silico predictions for acute effects assessment of biocidal active substances and metabolites for aquatic organisms
Ecotoxicology and Environmental Safety | 205
DOI: 10.1016/j.ecoenv.2020.111291
Sánchez Jiménez, A., Puelles, R., Pérez-Fernández, M., Gómez-Fernández, P., Barruetabeña, L., Jacobsen, N.R., Suarez-Merino, B., Micheletti, C., Manier, N., Trouiller, B., Navas, J.M., Kalman, J., Salieri, B., Hischier, R., Handzhiyski, Y., Apostolova, M.D., Hadrup, N., Bouillard, J., Oudart, Y., Merino, C., Garcia, E., Liguori, B., Sabella, S., Rose, J., Masion, A., Galea, K.S., Kelly, S., Štěpánková, S., Mouneyrac, C., Barrick, A., Châtel, A., Dusinska, M., Rundén-Pran, E., Mariussen, E., Bressot, C., Aguerre-Chariol, O., Shandilya, N., Goede, H., Gomez-Cordon, J., Simar, S., Nesslany, F., Jensen, K.A., van Tongeren, M., Rodríguez Llopis, I. (2020)
Safe(r) by design implementation in the nanotechnology industry
NanoImpact | 20
DOI: 10.1016/j.impact.2020.100267
Martínez-Gómez, C., Valdehita, A., Vethaak, A.D., Navas, J.M., León, V.M. (2020)
Toxicity characterization of surface sediments from a Mediterranean coastal lagoon
Chemosphere | 253
DOI: 10.1016/j.chemosphere.2020.126710
Hernández-Moreno, D., Morales, S., Camello-Almaraz, C., Pozo, M.J., Camello, P.J. (2020)
Monochloramine effects on gallbladder contractility
Clinical and Experimental Pharmacology and Physiology
DOI: 10.1111/1440-1681.13453
Spevakova, I., Fernandez-Cruz, M.-L., Tokarova, K., Greifova, H., Capcarova, M. (2020)
The protective effect of stilbenes resveratrol and pterostilbene individually and combined with mycotoxin citrinin in human adenocarcinoma HT-29 cell line in vitro
Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering | 56 : 75-88
DOI: 10.1080/10934529.2020.1839279
Hernández-Moreno, D., Valdehita, A., Conde, E., Rucandio, I., Navas, J.M., Fernández-Cruz, M.L. (2019)
Acute toxic effects caused by the co-exposure of nanoparticles of ZnO and Cu in rainbow trout
Science of the Total Environment | 687 : 24-33
DOI: 10.1016/j.scitotenv.2019.06.084
Barrick, A., Châtel, A., Manier, N., Kalman, J., Navas, J.M., Mouneyrac, C. (2019)
Investigating the Impact of Manufacturing Processes on the Ecotoxicity of Carbon Nanofibers: A Multi–Aquatic Species Comparison
Environmental Toxicology and Chemistry | 38 : 2314-2325
DOI: 10.1002/etc.4537
García-Herranz, V., Valdehita, A., Navas, J.M., Fernández-Cruz, M.L. (2019)
Cytotoxicity against fish and mammalian cell lines and endocrine activity of the mycotoxins beauvericin, deoxynivalenol and ochratoxin-A
Food and Chemical Toxicology | 127 : 288-297
DOI: 10.1016/j.fct.2019.01.036
Blázquez, M., Fernández-Cruz, M.L., Gajewicz, A., Puzyn, T., Benfenati, E. (2019)
On the uses of predictive toxicology to approve the use of engineered nanomaterials as biocidal active substances under the Biocidal Products Regulation
IOP Conference Series: Materials Science and Engineering | 499
DOI: 10.1088/1757-899X/499/1/012007
Giusti, A., Atluri, R., Tsekovska, R., Gajewicz, A., Apostolova, M.D., Battistelli, C.L., Bleeker, E.A.J., Bossa, C., Bouillard, J., Dusinska, M., Gómez-Fernández, P., Grafström, R., Gromelski, M., Handzhiyski, Y., Jacobsen, N.R., Jantunen, P., Jensen, K.A., Mech, A., Navas, J.M., Nymark, P., Oomen, A.G., Puzyn, T., Rasmussen, K., Riebeling, C., Rodriguez-Llopis, I., Sabella, S., Sintes, J.R., Suarez-Merino, B., Tanasescu, S., Wallin, H., Haase, A. (2019)
Nanomaterial grouping: Existing approaches and future recommendations
NanoImpact | 16
DOI: 10.1016/j.impact.2019.100182
Hernández-Moreno, D., Blázquez, M., Andreu-Sánchez, O., Bermejo-Nogales, A., Fernández-Cruz, M.L. (2019)
Acute hazard of biocides for the aquatic environmental compartment from a life-cycle perspective
Science of the Total Environment | 658 : 416-423
DOI: 10.1016/j.scitotenv.2018.12.186
Kalman, J., Merino, C., Fernández-Cruz, M.L., Navas, J.M. (2019)
Usefulness of fish cell lines for the initial characterization of toxicity and cellular fate of graphene-related materials (carbon nanofibers and graphene oxide)
Chemosphere | 218 : 347-358
DOI: 10.1016/j.chemosphere.2018.11.130
Vizuete, J., Hernández-Moreno, D., Fidalgo, L.E., Bertini, S., Andreini, R., Soler, F., Míguez-Santiyán, M.P., López-Beceiro, A., Pérez-López, M. (2018)
Concentrations of chlorinated pollutants in adipose tissue of yellow-legged gulls (Larus michahellis) from Spain: Role of gender and age
Ecotoxicology and Environmental Safety | 164 : 493-499
DOI: 10.1016/j.ecoenv.2018.08.060
Hernández-Moreno, D., Míguez, M.P., Soler, F., Pérez-López, M. (2018)
Influence of sex on biomarkers of oxidative stress in the kidney, lungs, and liver of rabbits after exposure to diazinon
Environmental Science and Pollution Research | 25 : 32458-32465
DOI: 10.1007/s11356-018-3258-6
Galbis-Martínez, L., Fernández-Cruz, M.L., Alte, L., Valdehita, A., Rucandio, I., Navas, J.M. (2018)
Development of a new tool for the long term in vitro ecotoxicity testing of nanomaterials using a rainbow-trout cell line (RTL-W1)
Toxicology in Vitro | 50 : 305-317
DOI: 10.1016/j.tiv.2018.04.007
Valcárcel, Y., Valdehíta, A., Becerra, E., López de Alda, M., Gil, A., Gorga, M., Petrovic, M., Barceló, D., Navas, J.M. (2018)
Determining the presence of chemicals with suspected endocrine activity in drinking water from the Madrid region (Spain) and assessment of their estrogenic, androgenic and thyroidal activities
Chemosphere | 201 : 388-398
DOI: 10.1016/j.chemosphere.2018.02.099
Furley, T.H., Brodeur, J., Silva de Assis, H.C., Carriquiriborde, P., Chagas, K.R., Corrales, J., Denadai, M., Fuchs, J., Mascarenhas, R., Miglioranza, K.S.B., Miguez Caramés, D.M., Navas, J.M., Nugegoda, D., Planes, E., Rodriguez-Jorquera, I.A., Orozco-Medina, M., Boxall, A.B.A., Rudd, M.A., Brooks, B.W. (2018)
Toward sustainable environmental quality: Identifying priority research questions for Latin America
Integrated Environmental Assessment and Management | 14 : 344-357
DOI: 10.1002/ieam.2023
Amorim, M.J.B., Lin, S., Schlich, K., Navas, J.M., Brunelli, A., Neubauer, N., Vilsmeier, K., Costa, A.L., Gondikas, A., Xia, T., Galbis, L., Badetti, E., Marcomini, A., Hristozov, D., Kammer, F.V.D., Hund-Rinke, K., Scott-Fordsmand, J.J., Nel, A., Wohlleben, W. (2018)
Environmental Impacts by Fragments Released from Nanoenabled Products: A Multiassay, Multimaterial Exploration by the SUN Approach
Environmental Science and Technology | 52 : 1514-1524
DOI: 10.1021/acs.est.7b04122
Calado, T., Fernández-Cruz, M.L., Cabo Verde, S., Venâncio, A., Abrunhosa, L. (2018)
Gamma irradiation effects on ochratoxin A: Degradation, cytotoxicity and application in food
Food Chemistry | 240 : 463-471
DOI: 10.1016/j.foodchem.2017.07.136
Pérez-Sánchez, J., Simó-Mirabet, P., Naya-Català, F., Martos-Sitcha, J.A., Perera, E., Bermejo-Nogales, A., Benedito-Palos, L., Calduch-Giner, J.A. (2018)
Somatotropic axis regulation unravels the differential effects of nutritional and environmental factors in growth performance of marine farmed fishes
Frontiers in Endocrinology | 9
DOI: 10.3389/fendo.2018.00687
Handy, R.D., Ahtiainen, J., Navas, J.M., Goss, G., Bleeker, E.A.J., Von Der Kammer, F. (2018)
Proposal for a tiered dietary bioaccumulation testing strategy for engineered nanomaterials using fish
Environmental Science: Nano | 5 : 2030-2046
DOI: 10.1039/c7en01139c
Scott-Fordsmand, J.J., Navas, J.M., Hund-Rinke, K., Nowack, B., Amorim, M.J.B. (2017)
Nanomaterials to microplastics: Swings and roundabouts
Nano Today | 17 : 7-10
DOI: 10.1016/j.nantod.2017.09.002
Bermejo-Nogales, A., Fernández-Cruz, M.L., Navas, J.M. (2017)
Fish cell lines as a tool for the ecotoxicity assessment and ranking of engineered nanomaterials
Regulatory Toxicology and Pharmacology | 90 : 297-307
DOI: 10.1016/j.yrtph.2017.09.029
Muñiz, S., Gonzalvo, P., Valdehita, A., Molina-Molina, J.M., Navas, J.M., Olea, N., Fernández-Cascán, J., Navarro, E. (2017)
Ecotoxicological assessment of soils polluted with chemical waste from lindane production: Use of bacterial communities and earthworms as bioremediation tools
Ecotoxicology and Environmental Safety | 145 : 539-548
DOI: 10.1016/j.ecoenv.2017.07.070
Habila, S., Leghouchi, E., Valdehita, A., Bermejo-Nogales, A., Khelili, S., Navas, J.M. (2017)
Induction of EROD and BFCOD activities in tissues of barbel (Barbus callensis) from a water reservoir in Algeria
Ecotoxicology and Environmental Safety | 142 : 129-138
DOI: 10.1016/j.ecoenv.2017.03.055
Martos-Sitcha, J.A., Bermejo-Nogales, A., Calduch-Giner, J.A., Pérez-Sánchez, J. (2017)
Gene expression profiling of whole blood cells supports a more efficient mitochondrial respiration in hypoxia-challenged gilthead sea bream (Sparus aurata)
Frontiers in Zoology | 14
DOI: 10.1186/s12983-017-0220-2
Valdehita, A., Fernández-Cruz, M.-L., González-Gullón, M.I., Becerra-Neira, E., Delgado, M.M., García-González, M.C., Navas, J.M. (2017)
Androgens and androgenic activity in broiler manure assessed by means of chemical analyses and in vitro bioassays
Environmental Toxicology and Chemistry | 36 : 1746-1754
DOI: 10.1002/etc.3495
Neila, C., Hernández-Moreno, D., Fidalgo, L.E., López-Beceiro, A., Soler, F., Pérez-López, M. (2017)
Does gender influence the levels of heavy metals in liver of wild boar?
Ecotoxicology and Environmental Safety | 140 : 24-29
DOI: 10.1016/j.ecoenv.2017.02.025
Bermejo-Nogales, A., Connolly, M., Rosenkranz, P., Fernández-Cruz, M.-L., Navas, J.M. (2017)
Negligible cytotoxicity induced by different titanium dioxide nanoparticles in fish cell lines
Ecotoxicology and Environmental Safety | 138 : 309-319
DOI: 10.1016/j.ecoenv.2016.12.039
Polloni-Silva, J., Valdehita, A., Fracácio, R., Navas, J.M. (2017)
Remediation efficiency of three treatments on water polluted with endocrine disruptors: Assessment by means of in vitro techniques
Chemosphere | 173 : 267-274
DOI: 10.1016/j.chemosphere.2017.01.029
Simó-Mirabet, P., Bermejo-Nogales, A., Calduch-Giner, J.A., Pérez-Sánchez, J. (2017)
Tissue-specific gene expression and fasting regulation of sirtuin family in gilthead sea bream (Sparus aurata)
Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology | 187 : 153-163
DOI: 10.1007/s00360-016-1014-0
Bermejo-Nogales, A., Fernández, M., Fernández-Cruz, M.L., Navas, J.M. (2016)
Effects of a silver nanomaterial on cellular organelles and time course of oxidative stress in a fish cell line (PLHC-1)
Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology | 190 : 54-65
DOI: 10.1016/j.cbpc.2016.08.004
Pasanisi, E., Cortés-Gómez, A.A., Pérez-López, M., Soler, F., Hernández-Moreno, D., Guerranti, C., Martellini, T., Fuentes-Mascorro, G., Romero, D., Cincinelli, A. (2016)
Levels of perfluorinated acids (PFCAs) in different tissues of Lepidochelys olivacea sea turtles from the Escobilla beach (Oaxaca, Mexico)
Science of the Total Environment | 572 : 1059-1065
DOI: 10.1016/j.scitotenv.2016.08.013
Hund-Rinke, K., Baun, A., Cupi, D., Fernandes, T.F., Handy, R., Kinross, J.H., Navas, J.M., Peijnenburg, W., Schlich, K., Shaw, B.J., Scott-Fordsmand, J.J. (2016)
Regulatory ecotoxicity testing of nanomaterials–proposed modifications of OECD test guidelines based on laboratory experience with silver and titanium dioxide nanoparticles
Nanotoxicology | 10 : 1442-1447
DOI: 10.1080/17435390.2016.1229517
Fernández-Cruz, M.L., Martín-Cabrejas, I., Pérez-del Palacio, J., Gaya, P., Díaz-Navarro, C., Navas, J.M., Medina, M., Arqués, J.L. (2016)
In vitro toxicity of reuterin, a potential food biopreservative
Food and Chemical Toxicology | 96 : 155-159
DOI: 10.1016/j.fct.2016.08.002
Hernández-Moreno, D., Li, L., Connolly, M., Conde, E., Fernández, M., Schuster, M., Navas, J.M., Fernández-Cruz, M.-L. (2016)
Mechanisms underlying the enhancement of toxicity caused by the coincubation of zinc oxide and copper nanoparticles in a fish hepatoma cell line
Environmental Toxicology and Chemistry | 35 : 2562-2570
DOI: 10.1002/etc.3425
Quesada-García, A., Encinas, P., Valdehita, A., Baumann, L., Segner, H., Coll, J.M., Navas, J.M. (2016)
Thyroid active agents T3 and PTU differentially affect immune gene transcripts in the head kidney of rainbow trout (Oncorynchus mykiss)
Aquatic Toxicology | 174 : 159-168
DOI: 10.1016/j.aquatox.2016.02.016
Cano-Sancho, G., González-Arias, C.A., Ramos, A.J., Sanchis, V., Fernández-Cruz, M.L. (2015)
Cytotoxicity of the mycotoxins deoxynivalenol and ochratoxin A on Caco-2 cell line in presence of resveratrol
Toxicology in Vitro | 29 : 1639-1646
DOI: 10.1016/j.tiv.2015.06.020
Lammel, T., Boisseaux, P., Navas, J.M. (2015)
Potentiating effect of graphene nanomaterials on aromatic environmental pollutant-induced cytochrome P450 1A expression in the topminnow fish hepatoma cell line PLHC-1
Environmental Toxicology | 30 : 1192-1204
DOI: 10.1002/tox.21991
Connolly, M., Fernandez-Cruz, M.-L., Quesada-Garcia, A., Alte, L., Segner, H., Navas, J.M. (2015)
Comparative cytotoxicity study of silver nanoparticles (Agnps) in a variety of rainbow trout cell lines (RTL-W1, RTH-149, RTG-2) and primary hepatocytes
International Journal of Environmental Research and Public Health | 12 : 5386-5405
DOI: 10.3390/ijerph120505386
Quesada-García, A., Valdehita, A., Del Olmo, I., Gómez, M.J., Navas, J.M. (2015)
Detection of Effects Caused by Very Low Levels of Contaminants in Riverine Sediments Through a Combination of Chemical Analysis, in Vitro Bioassays, and Farmed Fish as Sentinel
Archives of Environmental Contamination and Toxicology | 68 : 663-677
DOI: 10.1007/s00244-014-0127-2
Bermejo-Nogales, A., Calduch-Giner, J.A., Pérez-Sánchez, J. (2015)
Unraveling the molecular signatures of oxidative phosphorylation to cope with the nutritionally changing metabolic capabilities of liver and muscle tissues in farmed fish
PLoS ONE | 10
DOI: 10.1371/journal.pone.0122889
Connolly, M., Fernández-Cruz, M.L., Navas, J.M. (2015)
Recovery of redox homeostasis altered by CuNPs in H4IIE liver cells does not reduce the cytotoxic effects of these NPs: An investigation using aryl hydrocarbon receptor (AhR) dependent antioxidant activity
Chemico-Biological Interactions | 228 : 57-68
DOI: 10.1016/j.cbi.2015.01.012
Li, L., Fernández-Cruz, M.L., Connolly, M., Conde, E., Fernández, M., Schuster, M., Navas, J.M. (2015)
The potentiation effect makes the difference: Non-toxic concentrations of ZnO nanoparticles enhance Cu nanoparticle toxicity in vitro
Science of the Total Environment | 505 : 253-260
DOI: 10.1016/j.scitotenv.2014.10.020
Mary, V.S., Valdehita, A., Navas, J.M., Rubinstein, H.R., Fernández-Cruz, M.L. (2015)
Effects of aflatoxin B1, fumonisin B1 and their mixture on the aryl hydrocarbon receptor and cytochrome P450 1A induction
Food and Chemical Toxicology | 75 : 104-111
DOI: 10.1016/j.fct.2014.10.030
Li, L., Fernández-Cruz, M.L., Connolly, M., Schuster, M., Navas, J.M. (2015)
Dissolution and aggregation of Cu nanoparticles in culture media: effects of incubation temperature and particles size
Journal of Nanoparticle Research | 17
DOI: 10.1007/s11051-015-2865-0
Song, L., Connolly, M., Fernández-Cruz, M.L., Vijver, M.G., Fernández, M., Conde, E., De Snoo, G.R., Peijnenburg, W.J.G.M., Navas, J.M. (2014)
Species-specific toxicity of copper nanoparticles among mammalian and piscine cell lines
Nanotoxicology | 8 : 383-393
DOI: 10.3109/17435390.2013.790997
Lammel, T., Navas, J.M. (2014)
Graphene nanoplatelets spontaneously translocate into the cytosol and physically interact with cellular organelles in the fish cell line PLHC-1
Aquatic Toxicology | 150 : 55-65
DOI: 10.1016/j.aquatox.2014.02.016
De La Casa-Resino, I., Navas, J.M., Fernández-Cruz, M.L. (2014)
Chlorotriazines do not activate the aryl hydrocarbon receptor, the oestrogen receptor or the thyroid receptor in in vitro assays
ATLA Alternatives to Laboratory Animals | 42 : 25-30
DOI: 10.1177/026119291404200105
Quesada-García, A., Valdehita, A., Kropf, C., Casanova-Nakayama, A., Segner, H., Navas, J.M. (2014)
Thyroid signaling in immune organs and cells of the teleost fish rainbow trout (Oncorhynchus mykiss)
Fish and Shellfish Immunology | 38 : 166-174
DOI: 10.1016/j.fsi.2014.03.016
Oliveira, E., Casado, M., Faria, M., Soares, A.M.V.M., Navas, J.M., Barata, C., Piña, B. (2014)
Transcriptomic response of zebrafish embryos to polyaminoamine (PAMAM) dendrimers
Nanotoxicology | 8 : 92-99
DOI: 10.3109/17435390.2013.858376
Tetko, I.V., Schramm, K.-W., Knepper, T., Peijnenburg, W.J.G.M., Hendriks, A.J., Navas, J.M., Nicholls, I.A., Öberg, T., Todeschini, R., Schlosser, E., Brandmaier, S. (2014)
Experimental and theoretical studies in the EU FP7 Marie Curie initial training network project, environmental chemoinformatics (ECO)
ATLA Alternatives to Laboratory Animals | 42 : 7-11
DOI: 10.1177/026119291404200103
Scholz, S., Sela, E., Blaha, L., Braunbeck, T., Galay-Burgos, M., García-Franco, M., Guinea, J., Klüver, N., Schirmer, K., Tanneberger, K., Tobor-Kapłon, M., Witters, H., Belanger, S., Benfenati, E., Creton, S., Cronin, M.T.D., Eggen, R.I.L., Embry, M., Ekman, D., Gourmelon, A., Halder, M., Hardy, B., Hartung, T., Hubesch, B., Jungmann, D., Lampi, M.A., Lee, L., Léonard, M., Küster, E., Lillicrap, A., Luckenbach, T., Murk, A.J., Navas, J.M., Peijnenburg, W., Repetto, G., Salinas, E., Schüürmann, G., Spielmann, H., Tollefsen, K.E., Walter-Rohde, S., Whale, G., Wheeler, J.R., Winter, M.J. (2013)
A European perspective on alternatives to animal testing for environmental hazard identification and risk assessment
Regulatory Toxicology and Pharmacology | 67 : 506-530
DOI: 10.1016/j.yrtph.2013.10.003
De La Casa-Resino, I., Hernández-Moreno, D., Navas, J.M., Soler, F., Pérez-López, M. (2013)
Non-destructive multibiomarker approach in European quail (Coturnix coturnix coturnix) exposed to the herbicide atrazine
Archives of Environmental Contamination and Toxicology | 65 : 567-574
DOI: 10.1007/s00244-013-9907-3
Fernández-Cruz, M.L., Lammel, T., Connolly, M., Conde, E., Barrado, A.I., Derick, S., Perez, Y., Fernandez, M., Furger, C., Navas, J.M. (2013)
Comparative cytotoxicity induced by bulk and nanoparticulated ZnO in the fish and human hepatoma cell lines PLHC-1 and Hep G2
Nanotoxicology | 7 : 935-952
DOI: 10.3109/17435390.2012.676098
Cockburn, A., Brambilla, G., Fernández-Cruz, M.L., Arcella, D., Bordajandi, L.R., Cottrill, B., van Peteghem, C., Dorne, J.-L. (2013)
Nitrite in feed: From animal health to human health
Toxicology and Applied Pharmacology | 270 : 209-217
DOI: 10.1016/j.taap.2010.11.008
Dorne, J.L.C.M., Fernández-Cruz, M.L., Bertelsen, U., Renshaw, D.W., Peltonen, K., Anadon, A., Feil, A., Sanders, P., Wester, P., Fink-Gremmels, J. (2013)
Risk assessment of coccidostatics during feed cross-contamination: Animal and human health aspects
Toxicology and Applied Pharmacology | 270 : 196-208
DOI: 10.1016/j.taap.2010.12.014
Lammel, T., Boisseaux, P., Fernández-Cruz, M.-L., Navas, J.M. (2013)
Internalization and cytotoxicity of graphene oxide and carboxyl graphene nanoplatelets in the human hepatocellular carcinoma cell line Hep G2
Particle and Fibre Toxicology | 10
DOI: 10.1186/1743-8977-10-27
Malhão, F., Urbatzka, R., Navas, J.M., Cruzeiro, C., Monteiro, R.A.F., Rocha, E. (2013)
Cytological, immunocytochemical, ultrastructural and growth characterization of the rainbow trout liver cell line RTL-W1
Tissue and Cell | 45 : 159-174
DOI: 10.1016/j.tice.2012.10.006
Connolly, M., Pérez, Y., Mann, E., Herradón, B., Fernández-Cruz, M.L., Navas, J.M. (2013)
Peptide-biphenyl hybrid-capped AuNPs: Stability and biocompatibility under cell culture conditions
Nanoscale Research Letters | 8 : 1-21
DOI: 10.1186/1556-276X-8-315
Mezcua, M., Martínez-Uroz, M.A., Gómez-Ramos, M.M., Gómez, M.J., Navas, J.M., Fernández-Alba, A.R. (2012)
Analysis of synthetic endocrine-disrupting chemicals in food: A review
Talanta | 100 : 90-106
DOI: 10.1016/j.talanta.2012.07.078
Rosenkranz, P., Fernández-Cruz, M.L., Conde, E., Ramírez-Fernández, M.B., Flores, J.C., Fernández, M., Navas, J.M. (2012)
Effects of cerium oxide nanoparticles to fish and mammalian cell lines: An assessment of cytotoxicity and methodology
Toxicology in Vitro | 26 : 888-896
DOI: 10.1016/j.tiv.2012.04.019
Valdehita, A., Fernández-Cruz, M.L., Torrent, F., Sericano, J.L., Navas, J.M. (2012)
Differences in the induction of cyp1A and related genes in cultured rainbow trout Oncorhynchus mykiss. Additional considerations for the use of EROD activity as a biomarker
Journal of Fish Biology | 81 : 270-287
DOI: 10.1111/j.1095-8649.2012.03338.x
Raldúa, D., Barata, C., Casado, M., Faria, M., Navas, J.M., Olivares, A., Oliveira, E., Pelayo, S., Thienpont, B., Piña, B. (2012)
Zebrafish as a Vertebrate Model to Assess Sublethal Effects and Health Risks of Emerging Pollutants
Handbook of Environmental Chemistry | 20 : 395-414
DOI: 10.1007/698_2011_124
De La Casa-Resino, I., Valdehita, A., Soler, F., Navas, J.M., Pérez-López, M. (2012)
Endocrine disruption caused by oral administration of atrazine in European quail (Coturnix coturnix coturnix)
Comparative Biochemistry and Physiology - C Toxicology and Pharmacology | 156 : 159-165
DOI: 10.1016/j.cbpc.2012.07.006
Fernández-Cruz, M.L., Valdehita, A., Alonso, M., Mann, E., Herradón, B., Navas, J.M. (2011)
Biological and chemical studies on aryl hydrocarbon receptor induction by the p53 inhibitor pifithrin-α and its condensation product pifithrin-β
Life Sciences | 88 : 774-783
DOI: 10.1016/j.lfs.2011.02.019
Bosch, C., Olivares, A., Faria, M., Navas, J.M., del Olmo, I., Grimalt, J.O., Piña, B., Barata, C. (2009)
Identification of water soluble and particle bound compounds causing sublethal toxic effects. A field study on sediments affected by a chlor-alkali industry
Aquatic Toxicology | 94 : 16-27
DOI: 10.1016/j.aquatox.2009.05.011
Navas, J.M., Segner, H. (2008)
In-vitro screening of the antiestrogenic activity of chemicals
Expert Opinion on Drug Metabolism and Toxicology | 4 : 605-617
DOI: 10.1517/17425255.4.5.605
Alonso, M., Casado, S., Miranda, C., Tarazona, J.V., Navas, J.M., Herradón, B. (2008)
Decabromobiphenyl (PBB-209) activates the aryl hydrocarbon receptor while decachlorobiphenyl (PCB-209) is inactive: Experimental evidence and computational rationalization of the different behavior of some halogenated biphenyls
Chemical Research in Toxicology | 21 : 643-658
DOI: 10.1021/tx700362u
Jos, A., Segner, H., Herradón, B., Repetto, G., Navas, J.M. (2007)
Induction of EROD activity by 1-phenylimidazole and β-naphthoflavone in rainbow trout cultured hepatocytes: A comparative study
Toxicology in Vitro | 21 : 1307-1310
DOI: 10.1016/j.tiv.2007.03.017
Boronat, S., Casado, S., Navas, J.M., Piña, B. (2007)
Modulation of aryl hydrocarbon receptor transactivation by carbaryl, a nonconventional ligand
FEBS Journal | 274 : 3327-3339
DOI: 10.1111/j.1742-4658.2007.05867.x
Navas, J.M., Segner, H. (2006)
Vitellogenin synthesis in primary cultures of fish liver cells as endpoint for in vitro screening of the (anti)estrogenic activity of chemical substances
Aquatic Toxicology | 80 : 1-22
DOI: 10.1016/j.aquatox.2006.07.013
Fernández-Cruz, M.L., Barreda, M., Villarroya, M., Peruga, A., Llanos, S., García-Baudín, J.M. (2006)
Captan and fenitrothion dissipation in field-treated cauliflowers and effect of household processing
Pest Management Science | 62 : 637-645
DOI: 10.1002/ps.1217
Fernández-Cruz, M.L., Grimalt, S., Villarroya, M., López, F.J., Llanos, S., García-Baudín, J.M. (2006)
Residue levels of captan and trichlorfon in field-treated kaki fruits, individual versus composite samples, and after household processing
Food Additives and Contaminants | 23 : 591-600
DOI: 10.1080/02652030500529460
Grimalt, S., Sancho, J.V., Pozo, Ó.J., García-Baudin, J.M., Fernández-Cruz, M.L., Hernández, F. (2006)
Analytical study of trichlorfon residues in kaki fruit and cauliflower samples by liquid chromatography-electrospray tandem mass spectrometry
Journal of Agricultural and Food Chemistry | 54 : 1188-1195
DOI: 10.1021/jf052737j
Navas, J.M., Merino, R., Jiménez, B., Rivera, J., Abad, E., Zanuy, S., Carrillo, M. (2005)
Organochlorine compounds in liver and concentrations of vitellogenin and 17β-estradiol in plasma of sea bass fed with a commercial or with a natural diet
Aquatic Toxicology | 75 : 306-315
DOI: 10.1016/j.aquatox.2005.07.014
Babín, M., Casado, S., Chana, A., Herradón, B., Segner, H., Tarazona, J.V., Navas, J.M. (2005)
Cytochrome P4501A induction caused by the imidazole derivative Prochloraz in a rainbow trout cell line
Toxicology in Vitro | 19 : 899-902
DOI: 10.1016/j.tiv.2005.06.037
Navas, J.M., Chana, A., Herradón, B., Segner, H. (2004)
Induction of cytochrome P4501A (CYP1A) by clotrimazole, a non-planar aromatic compound. Computational studies on structural features of clotrimazole and related imidazole derivatives
Life Sciences | 76 : 699-714
DOI: 10.1016/j.lfs.2004.09.015

Maria Luisa Fernández Cruz
Towards harmonised test methods for nanomaterials
2020 - 2023 | 885931
José María Navas
Graphene Flagship Core Project 3
2020 - 2023 | 881603
Azucena Bermejo Nogales
Caracterización de mutaciones relacionadas con resistencias a rodenticidas en España e incidencia en poblaciones de roedores.
2020 - 2023 | PID2019-108053RJ-I00
José María Navas
Advanced High Aspect Ratio and Multicomponent materials: towards comprehensive intelLigent tEsting and Safe by design Strategies
2021 - 2025 | 953183
José María Navas
A INIA para la realización de trabajos sobre productos químicos y nanomateriales
2021 - 2024 | 20214TE004
Maria Luisa Fernández Cruz
Toxicity of nanomaterials (NMs) against fish and implementation of OECD TG 249 for NMs
2022 - 2024 | UCRAN20102
David Hernández Moreno y Azucena Bermejo Nogales
Protocolo para la evaluación de compuestos alternativos al uso de rodenticidas anticoagulantes
2022 - 2024 | TED2021-131186B-I00
David Hernández Moreno
Evaluación de efectos tóxicos mediante el uso de métodos alternativos: ensayos con embriones de pez cebra
2022 - 2023 | 202240I175
Azucena Bermejo Nogales
Identificación de rutas alternativas implicadas en la resistencia a rodenticidas
2022 - 2023 | 202240I172
Maria Luisa Fernández Cruz y David Hernández Moreno
MicoMixFishFeed: Riesgos de exposición prolongada a mezclas de micotoxinas presentes en piensos para peces.
2022 - 2025 | PID2021-126947OR-I00
José María Navas
Agreement AEG09-036 between INIA and the Ministry of Environment for the national implementation and application of the Stockholm Convention and the regulation 850/2004/CE about Persistent Organic Pollutants (POPs)
2009 - 1899 | AEG09-036
José María Navas
Agreement AEG07-060 between INIA and the Ministry of Environment to aply the REACH Regulation and related rules including those of Biocides and Plant Protection Products
2009 - 1899 | AEG07-060
José María Navas y María Luisa Fernández Cruz
Agreement EG13-074 between INIA and the General Direction of Environment Quality and Evaluation for the environmental risk assessment of substances and chemical products according to the National and European regulations
2013 - 1899 | EG13-074
María Luisa Fernández-Cruz
Agreement EG17-017 between INIA and the General Direction of Environment Quality and Evaluation related to Substances y chemical mixtures: environmenatl risk assessment, identification of endocrine disruptors and nanomaterials and uses control
2017 - 1899 | EG17-017
José María Navas
“Endocrine disruption related to farm residues”.
2009 - 1899 | RTA2009-00074-00-00
María Luisa Fernández-Cruz
“Scientific cooperation for the search of strategies of control and prevention of mycotoxins in agricultural production”. CYTED IBEROAMERICA. July 2011
2011 - 1899 | 109Ac0371
José María Navas
FP7 People. Marie-Curie. Initial Training Network (ITN). “ECO. Environmental ChemOinformatics”.
2009 - 1899 |
José María Navas
FP7 Project MARINA. Managing Risks of Nanomaterials.
2011 - 1899 |
José María Navas
National Project: “Endocrine disruption and toxic effects related to the presence of hormones, antibiotics, mycotoxins and other substances in farm residues”
2013 - 1899 | RTA2012-00053-00-00
José María Navas
FP7 Project SUN. “Sustainable Nanotechnologies”
2013 - 1899 | 604305
María Luisa Fernández Cruz
FP7 Project GUIDEnano. “Assessment and mitigation of nano-enabled product risks on human and environmental health: Development of new strategies and creation of a digital guidance tool for nanotech industries"
2013 - 1899 | nº 604387
José María Navas
H2020 Project NanoReg2. “Development and implementation Grouping and Safe-by-Design approaches within regulatory frameworks”
2015 - 1899 | 646221
María Luisa Fernández Cruz
LIFE-COMBASE “Computational tool for the assessment and substitution of Biocidal Active Substances of Ecotoxicological concern”
2016 - 2019 | LIFE15 ENV/ES/000416
José María Navas
H2020 Project-MSCA-IF-2016. “Spheroids as a Tool to Assess Realistic long term effects of mixtures of nanomaterials and chemicals (STARNANO)”. February 2018-January 2020.
2018 - 2020 | 746876
José María Navas
Graphene Flagship Programme “Graphene-Core 2”
2018 - 2020 | 785219
María Luisa Fernández-Cruz
“Use of nanotechnology to reduce the contamination by mycotoxins in fish feed”
2017 - 2021 | RTA2015-00041-00-00
María Luisa Fernández-Cruz
H2020 Project BIORIMA “BIOmaterial RIsk MAnagement”
2017 - 2021 | 760928
María Luisa Fernández Cruz
H2020 Project GOV4NANO “Implementation of Risk Governance: meeting the needs of nanotechnology”
2019 - 2022 | 814401
HELMHOLTZ ZENTRUM MUENCHEN HMGU, Alemania; ) & José María Navas.
HARMLESS. Advanced High Aspect Ratio and Multicomponent materials: towards comprehensive intelLigent tEsting and Safe by design Strategies.
2020 - 2024 | 953183
Thomas Kuhlbusch (BAUA, Germany) & María Luisa Fernández
NanoHarmony “Towards harmonised test methods for nanomaterials” (H2020 Grant Agreement 885931). European Comission.14 participants.
2020 - 2023 | 885931
José María Navas
Graphene-Core 3 (EU H2020, Grant Agreement 785219)
2020 - 2023 | 881603

Victor García Herranz (2022)
Interacción entre el receptor de hormonas tiroideas y contaminantes presentes en gallinaza
Dirección: María Luisa Fernández Cruz y José María Navas | Universidad Autónoma de Madrid
Sasana Casado
Mechanisms of activation of the aryl hydrocarbon receptor in fish
Dirección: José María Navas | Universidad Complutense de Madrid (UCM).
Tobias Lammel
New insights into the toxicity of nanomaterials obtained by means of fish and mammalian cell lines
Dirección: José María Navas | Universidad Autónoma de Madrid
Irene de la Casa Resino
Nuevos horizontes en Ecotoxicología: biomarcadores destructivos y no destructivos en codorniz (Coturnix coturnix) y cigüeña blanca (Ciconia ciconia).
Dirección: Marcos Pérez López, Francisco Soler Rodríguez y José María Navas | Universidad de Extremadura
Alba Quesada García
Expression and function of detoxification processes in fish and alterations of reproductive hormonal regulation
Dirección: José María Navas y Ana Valdehita | Universidad Autónoma de Madrid
Mona Connolly
Mechanisms underlying the toxic action of nanomaterials: in vitro and in vivo approaches
Dirección: José María Navas y María Luisa Fernández Cruz | Universidad Complutense de Madrid
Victor García Herranz
Thyroidal activity in manure. Determination of responsible substances
Dirección: José María Navas y María Luisa Fernández Cruz | Universidad Autónoma de Madrid